Ole Miss and Louisville combined for 79 points in a back-and-forth offensive showcase, with the Cardinals pulling off the upset despite playing on the road. Louisville covered the 6.5-point spread with a 38-41 victory that exceeded the 55-point over-under line.

The third quarter proved decisive, featuring several explosive plays from both offenses. Trinidad Chambliss led Ole Miss through the air with 336 passing yards, including two 62-yard touchdown passes to Deuce Alexander. Louisville's Lincoln Kienholz orchestrated a potent offensive attack, connecting with Tre Richardson for 83 receiving yards and engineering a 62-yard touchdown to Richardson that included a two-point conversion pass to Lawayne McCoy.

The fourth quarter remained tightly contested, with Ole Miss mounting a strong response before Louisville secured the win. The game featured 36 lead changes, reflecting the competitive nature of the Week 1 matchup. Louisville's defense made critical plays throughout, while Ole Miss kept the game within reach despite the final deficit. Carson Hilbert's extra point conversions proved crucial in the Cardinals' upset victory.