Louisville held a 27-22 lead entering the fourth quarter, but Toledo's offense came alive in the final period to secure a stunning 27-22 victory. The Cardinals, favored by 8.5 points, could not hold their advantage as the Rockets mounted a furious comeback.

Toledo quarterback Kalieb Osborne led the charge, finishing with 167 passing yards and 77 rushing yards. His 26-yard touchdown pass to Jacob Petersen, capped by a two-point conversion run by Chip Trayanum, proved pivotal in the comeback effort.

Louisville's offense struggled to respond in crunch time, with a crucial kneel-down play in the final moments resulting in a 28-yard loss. The Cardinals did produce one explosive play when Isaac Brown broke free for a 53-yard run in the fourth quarter, though the extra point was blocked.

Caullin Lacy led Louisville receivers with 88 yards. Despite early scoring in the first and third quarters, the Cardinals couldn't maintain their momentum against Toledo's fourth-quarter surge.

The game exceeded the over-under of 44.5 points, finishing with 49 combined points.