Old Dominion dominated South Florida 24-10 in a Week 1 matchup, with the Monarchs' defense creating crucial stops throughout the contest. The away team built an early 7-3 first-quarter lead and never trailed again, extending their advantage to 17-3 by halftime before pulling away in the second half.

Old Dominion's offensive explosion came through a pair of explosive plays, including a 51-yard run by Quinn Henicle in the fourth quarter and a 22-yard touchdown run by Trequan Jones in the third quarter. The Monarchs' defense generated four of the game's five most impactful plays, with strong performances in the first, third, and fourth quarters shutting down USF scoring opportunities.

South Florida managed only two first-half touchdowns and drew a blank in the second half. Locklan Hewlett led the Bulls' passing attack with 45 yards, while Jeremiah Koger was their top receiver with 68 yards. Old Dominion covered the 3-point spread, and the game finished well under the 54-point over-under at 34 total points.